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Towards a systematic classification of protein folds

American Physical Society
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  • A Lattice Model Hamiltonian Is Suggested For Protein Structures That Can Explain The Division Into S
  • Proteins Are Described By Chains Of Secondary Structure Elements
  • With The Hinges In Between Being The Important Degrees Of Freedom
  • The Protein Structures Are Given A Unique Name
  • Which Simultaneously Represent A Linear String Of Physical Coupling Constants Describing Hinge Spin
  • We Have Defined A Metric And A Precise Distance Measure Between The Fold Classes
  • An Automated Procedure Is Constructed In Which Any Protein Structure In The Usual Protein Data Base
  • Taking Into Account Hydrophobic Forces We Have Found A Mechanism For The Formation Of Domains With A
  • 6
  • 9
  • 12
  • 16
  • 18
  • } Of Secondary Structures And Multiples Of These Domains
  • It Is Shown That The Same Magic Numbers Are Robust And Occur As Well For Packing On Other Nonclosed
  • We Have Performed A Statistical Analysis Of Available Protein Structures And Found Agreement With Th
  • Thermodynamic Arguments For The Increased Abundance And A Phase Diagram For The Folding Scenario Are
  • This Includes An Intermediate High Symmetry Phase
  • The Parent Structures
  • Between The Molten Globule And The Native States
  • We Have Made An Exhaustive Enumeration Of Dense Lattice Animals On A Cubic Lattice For Acceptance Nu
  • Biology


Towards a systematic classification of protein folds - DTU Orbit (27/05/14) Towards a systematic classification of protein folds - DTU Orbit (27/05/14) Lindgård, Per-Anker; Bohr, Henrik / Towards a systematic classification of protein folds. In: Physical Review E. Statistical, Nonlinear, and Soft Matter Physics, Vol. 56, No. 4, 1997, p. 4497-4515. Publication: Research - peer-review › Journal article – Annual report year: 1997

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