Affordable Access

Publisher Website

Multidisciplinary management and emerging therapeutic strategies in aneurysmal subarachnoid haemorrhage

Authors
Journal
The Lancet Neurology
1474-4422
Publisher
Elsevier
Publication Date
Volume
9
Issue
5
Identifiers
DOI: 10.1016/s1474-4422(10)70087-9
Keywords
  • Review And Opinion
  • Review
Disciplines
  • Medicine

Abstract

Summary The management of patients with aneurysmal subarachnoid haemorrhage demands expertise to anticipate, recognise, and promptly treat the many neurological and systemic complications. For this reason, these patients are best cared for in high-volume medical centres with multidisciplinary teams and should preferably be treated in a specialised intensive care unit. Endovascular occlusion and surgical clipping provide complementary alternatives for the treatment of aneurysms. Perfusion scans are redefining the way we detect delayed ischaemia as a growing body of evidence indicates that monitoring vessel diameter is insufficient to prevent cerebral infarctions. Statins, endothelin antagonists, and magnesium sulfate infusion are among the novel strategies being tested for neuroprotection and attenuation of vasospasm. The effectiveness of these treatments is supported by strong experimental data and they represent a new generation of therapeutic options developed from the understanding that vasospasm is primarily caused by endothelial dysfunction.

There are no comments yet on this publication. Be the first to share your thoughts.