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A substance causing abnormal developmet of fungal hyphae produced byPenicillium janczewskiiZal:III. Identity of ‘curling factor’ with griseofulvin

Authors
Journal
Transactions of the British Mycological Society
0007-1536
Publisher
Elsevier
Publication Date
Volume
32
Issue
1
Identifiers
DOI: 10.1016/s0007-1536(49)80033-7

Abstract

Summary The ‘curling factor’ produced by Penicillium janczewskii has been shown to be identical with the substance known as griseofulvin (C 17H 17O 6Cl) previously isolated from the mycelium of P. griseofulvum and P. patulum. All strains of P. janczewskii examined, from different sources, have shown the capacity to produce griseofulvin, but not all strains of P. griseofulvum have done so. Yields of griseofulvin from P. janczewskii can be approximately doubled by extracting the mycelium as well as the culture filtrate; by this means yields of the order of 400 mg. per litre of culture medium have been obtained. A chlorine content of the medium corresponding to 0·005–0·01 % potassium chloride is optimum for griseofulvin production.

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