Abstract This paper presents the study of liver metastases and the role of radiation therapy in its management. A total of 27 patients were treated in the Radiation Therapy Department of Rush-Presbyterian-St. Luke's Medical Center between January 1973 and March 1975. The site of primary lesion, histology and interval between the detection of primary and liver metastases were studied in each case. The present study shows that liver irradiation is an effective way of managing patients with symptomatic liver metastases. Our study suggests selection of non-terminal patients for therapy. Roughly 70% of the total series of patients or 9596 of the group completing therapy showed symptomatic relief of pain. Jaundice and ascites improved in a small group as well. More than half of the patients with subjective improvement experienced regression in the liver size. No definite conclusion can be drawn about the effect of therapy on liver functions. The survival of patients is probably unchanged by therapy. The average survival since therapy was found to be 4 months.