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Electrochemical oxidation behavior of Acebutolol and identification of intermediate species by liquid chromatography and mass spectrometry

Authors
Journal
Electrochimica Acta
0013-4686
Publisher
Elsevier
Publication Date
Volume
69
Identifiers
DOI: 10.1016/j.electacta.2012.03.007
Keywords
  • Acebutolol
  • Aromatic Ether Cleavage
  • Electrochemical Oxidative Degradation
  • Ec-Lc–Ms
  • Emerging Pollutant
Disciplines
  • Chemistry

Abstract

Abstract The electrochemical behavior of Acebutolol was examined by cyclic voltammetry and coulometry. The products of Acebutolol oxidation were then characterized by liquid chromatography (LC) and mass spectrometry (MS). An aromatic ether cleavage reaction was observed and various intermediate species were identified. In the presence of glutathione, a series of glutathione adducts were identified enabling possible oxidation pathways of Acebutolol to be established. The obtained results are useful for predicting and understanding the oxidative Acebutolol degradation pathway.

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