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Aetiologies and risk factors for neonatal sepsis and pneumonia mortality among Alaskan infants.

Authors
  • Gessner, B D1
  • Castrodale, L
  • Soriano-Gabarro, M
  • 1 Alaska Division of Public Health, Section of Epidemiology, Anchorage, Alaska 99524, USA. [email protected]
Type
Published Article
Journal
Epidemiology and infection
Publication Date
Oct 01, 2005
Volume
133
Issue
5
Pages
877–881
Identifiers
PMID: 16181508
Source
Medline
License
Unknown

Abstract

We evaluated all fatal neonatal sepsis and pneumonia cases occurring in Alaska during 1992-2000. Risk factors were evaluated using a database of all births occurring during the study period. Of 32 cases, group B streptococcus (GBS) was isolated from 21% (all 7 days of age), non-GBS Gram-positive bacteria from 50% (53% <7 days of age), and Gram-negative infections from 38% (58% <7 days of age). Infants born at <37 weeks gestation accounted for 72% of cases and had an increased risk of GBS [rate ratio (RR) 9.1, 95% confidence interval (CI) 2.0-41] and non-GBS (RR 40, 95% CI 16-101) disease. Neonatal sepsis mortality has become an outcome concentrated among pre-term infants. Aetiologies include GBS during the early neonatal period, Candida spp. during the late neonatal period, and other bacteria during both periods.

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