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Aerosolized vaccine as an unexpected source of false-positive Bordetella pertussis PCR results.

Authors
  • Salimnia, Hossein
  • Lephart, Paul R
  • Asmar, Basim I
  • Prebelich, Dawn
  • Paulson, Erin
  • Fairfax, Marilynn R
Type
Published Article
Journal
Journal of Clinical Microbiology
Publisher
American Society for Microbiology
Publication Date
Feb 01, 2012
Volume
50
Issue
2
Pages
472–474
Identifiers
DOI: 10.1128/JCM.01250-11
PMID: 22162551
Source
Medline
License
Unknown

Abstract

When 13 of 13 nasal wash specimens from a single pediatrician's office tested positive for low quantities of Bordetella pertussis DNA, we suspected prelaboratory contamination. Investigation revealed that Pentacel and Adacel vaccines contain high copy numbers of B. pertussis DNA, which can be aerosolized, causing false-positive B. pertussis PCR results.

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