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Aerosolized LTB4 produces delayed onset increases in pulmonary gas trapping.

Authors
  • Silbaugh, S A
  • Stengel, P W
  • Cockerham, S L
  • Froelich, L L
  • Bendele, A M
  • Rippy, M K
  • Baker, S R
  • Sofia, M J
  • Jackson, W T
Type
Published Article
Journal
Prostaglandins Leukotrienes and Essential Fatty Acids
Publisher
Elsevier
Publication Date
Feb 01, 1996
Volume
54
Issue
2
Pages
115–121
Identifiers
PMID: 8848430
Source
Medline
License
Unknown

Abstract

Airway obstruction, as measured by increases in postmortem pulmonary gas trapping, and lung inflammatory changes were examined in guinea pigs exposed for up to 4 h to aerosols of leukotriene B4 (LTB4) or its non-chemotactic isomer, 6-trans-12-epi-LTB4. Airway obstruction and cytological responses in isomer-exposed animals were similar to those of unexposed control animals. LTB4-exposed animals had minimal inflammatory changes at 0.5 h but became dyspneic by 2 h and had increased airway obstruction, bronchoalveolar lavage neutrophils and eosinophils, and pulmonary tissue granulocyte scores. The LTB4-induced effects at 4 h were similar to those 2 h, except for further increase in BAL neutrophils and eosinophils. LTB4-induced airway obstructive and inflammatory changes were prevented by pretreatment with the LTB4 receptor antagonist SC-41930, but were unaffected by indomethacin. Thus, prolonged LTB4 inhalation can produce delayed onset airway obstruction that is stereospecific, cyclooxygenase-independent, and temporally associated with the influx of granulocytes into lung airways.

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