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Aerobic interval exercise improves renal functionality and affects mineral metabolism in obese Zucker rats.

Authors
  • Martinez, Rosario1
  • Kapravelou, Garifallia
  • López-Chaves, Carlos2
  • Cáceres, Elena2
  • Coll-Risco, Irene2
  • Sánchez-González, Cristina2
  • Llopis, Juan2
  • Arrebola, Francisco3
  • Galisteo, Milagros4
  • Aranda, Pilar5
  • Lopez-Jurado, Maria6
  • Porres, Jesus M5
  • 1 PHYSIOLOGY, UNIVERSITY OF GRANADA.
  • 2 Physiology, University of Granada, Spain. , (Spain)
  • 3 Histology, University of Granada.
  • 4 Pharmacology, University of Granada.
  • 5 Department of Physiology, School of Pharmacy and Institute of Nutrition and Food Technology., University of Granada. Spain., Spain. , (Spain)
  • 6 Department of Physiology, School of Pharmacy and Institute of Nutrition and Food Technology., University of Granada. Spain. , (Spain)
Type
Published Article
Journal
American journal of physiology. Renal physiology
Publication Date
Oct 10, 2018
Identifiers
DOI: 10.1152/ajprenal.00356.2018
PMID: 30303711
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Obesity, metabolic syndrome and renal injury are considered risk factors for type 2 diabetes, as well as kidney disease. Functional and structural changes in the kidney as consequence of obesity and metabolic syndrome may lead to impaired mineral metabolism in what is known as chronic kidney disease-mineral and bone disorder. Lifestyle interventions such as physical activity are good strategies to manage these pathologies and, therefore, prevent the loss of kidney functionality and related complications in mineral metabolism. In this study, we have used forty male Zucker rats that were randomly allocated into four different experimental groups, two of them (an obese and a lean one) performed an aerobic interval training protocol, and the other two groups were sedentary. At the end of the experimental period (8 weeks), urine, plasma and femur were collected for biochemical and mineral composition analysis, whereas the kidney was processed for histological studies. The obese rats exhibited albuminuria, glomerulosclerosis and hypertrophy in glomeruli and renal tubule in some areas, together with alterations in mineral content of plasma but not of femur. The training protocol prevented the generation of albuminuria and glomerulosclerosis, showing a significant action on plasma and bone mineral levels. Therefore, the specific training protocol used in this study was able to prevent the development of diabetic nephropathy, and affected the metabolism of certain minerals.

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