Affordable Access

Publisher Website

Identification of a public CDR3 motif and a biased utilization of T-cell receptor V beta and J beta chains in HLA-A2/Melan-A-specific T-cell clonotypes of melanoma patients.

Authors
  • 1
Type
Published Article
Journal
Journal of Translational Medicine
1479-5876
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
7
Pages
21–21
Identifiers
DOI: 10.1186/1479-5876-7-21
PMID: 19317896
Source
Medline

Abstract

Contrary to what observed for public anti-Melan-A T-cell receptor alpha motifs, which had been identified in several clonotypes of both melanoma patients and healthy controls, the unexpectedly high contribution of a public TRB motif in the recognition of a dominant melanoma epitope in melanoma patients may provide important information about the biology of anti-tumor T-cell responses and improve monitoring strategies of anti-tumor vaccines.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments