Affordable Access

Publisher Website

Arsenic is decreased in target organs during viral infection in mice

Authors
Journal
Journal of Trace Elements in Medicine and Biology
0946-672X
Publisher
Elsevier
Publication Date
Volume
20
Issue
2
Identifiers
DOI: 10.1016/j.jtemb.2005.12.002
Keywords
  • Arsenic
  • Organ
  • Virus
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Arsenic (As), a potentially toxic trace element, has been shown to influence viral replication and resistance to microbial infection. However, the impact of infection on the normal As status in target organs involved in the disease process has not been studied to date. In the present study, As was measured through inductively coupled plasma mass spectrometry in the plasma, liver, spleen, kidney, heart, pancreas and brain at days 1 and 3 of coxsackievirus B3 infection in female Balb/c mice. The severity of the infection was assessed from clinical signs of disease. The infection changed plasma As in a biphasic pattern with a small increase (n.s.) at day 1 that turned into a decreasing trend (13%, p<0.05) by day 3. In the liver, spleen, heart, pancreas and kidney As was unchanged at day 1 but, at day 3, it had decreased by 71% ( p<0.01), 64% ( p<0.01), 55% ( p<0.01), 63% ( p<0.01) and 73% ( p<0.01), respectively. In the brain, As went unchanged. The pathophysiological interpretation of these findings requires further research.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments