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Memory Assessment Battery and Early Identification of Dementia

Journal of Neural Transplantation and Plasticity
Hindawi Publishing Corporation
Publication Date
DOI: 10.1155/np.1992.187
  • Article
  • Biology
  • Medicine
  • Psychology


9.P4 Memory Assessment Battery and Early Identification of Dementia F. Ostrosky-Sols, Y. Rodr.guez, C. Garca de la Cadena, R.M. Jaime, A.M. Vald6s, R. Chayo-Dichi, D. Velazquez, M. P6rez, M. Guevara I. Madrazo* and C. Cuevas Department ofPsychophysiology, Graduate School, National University ofMexico, *Research Unit, Centro Mddico Siglo XXI, Mexico 187 Early identification of dementia is of great importance for the development of any potential therapy that attempts to prevent, delay or alter the progression of the disease. Furthermore, any potential treatment must be offered during early stages of the demential processes since it is during these stages that treatment is most likely to be of benefit. Effective assessment of treat- ment requires the use of reliable and sensitive measurements of the target functions. A promi- nent sign of dementia of the Alzheimer’s type (DAT) is a deficit in the ability to learn and remember new information. A battery of mem- ory functions was established including: a) neuropsychological measures of memory (immediate and delayed recall; learning; cued recall; and recognition for verbal and non-verbal material for auditory, visual and spatial infor- mation); b) electrophysiological measures linked to memory processes (late-event related poten- tials-P300 paradigm), and c) functional meas- ures of everyday memory. The battery of tests was applied to 66 healthy volunteers between 20 and 100 years of age. Subjects were divided into four age groups: 20-39, 40-59, 60-75, 76-100. Results showed that during aging not all aspects of memory and learning are equally affected. Some tests appeared particularly sensitive to the effects of aging (such as delayed recall in the visual and auditory modality for verbal and non- verbal information). For others, the effects of aging were minimally observed or not revealed at all (such as immediate memory for auditory, visual and spatial information). Electrophysio- logical measures showed that P300 latency increased in di

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