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Asexuals, Polyploids, Evolutionary Opportunists...: The Population Genetics of Positive but Deteriorating Mutations

Authors
Journal
Genetics
0016-6731
Publisher
The Genetics Society of America
Publication Date
Volume
191
Issue
4
Identifiers
DOI: 10.1534/genetics.112.140715
Keywords
  • Notes
  • Population And Evolutionary Genetics

Abstract

Some genetic phenomena originate as mutations that are initially advantageous but decline in fitness until they become distinctly deleterious. Here I give the condition for a mutation–selection balance to form and describe some of the properties of the resulting equilibrium population. A characterization is also given of the fixation probabilities for such mutations.

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