Affordable Access

Access to the full text

The Adverse Effects of Androgen Deprivation Therapy in Prostate Cancer and the Benefits and Potential Anti-oncogenic Mechanisms of Progressive Resistance Training

  • Lam, Teresa1, 2, 3
  • Birzniece, Vita1, 3, 4, 5, 6
  • McLean, Mark1, 3
  • Gurney, Howard7
  • Hayden, Amy7, 3
  • Cheema, Birinder S.8
  • 1 School of Medicine, Western Sydney University, Penrith, NSW, Australia , Penrith (Australia)
  • 2 Westmead Hospital, Westmead, NSW, Australia , Westmead (Australia)
  • 3 Blacktown Hospital, Blacktown, NSW, Australia , Blacktown (Australia)
  • 4 School of Medicine, UNSW Sydney, Sydney, NSW, Australia , Sydney (Australia)
  • 5 Garvan Institute of Medical Research, Darlinghurst, NSW, Australia , Darlinghurst (Australia)
  • 6 Translational Health Research Institute, Penrith, NSW, Australia , Penrith (Australia)
  • 7 Crown Princess Mary Cancer Centre, Westmead, NSW, Australia , Westmead (Australia)
  • 8 School of Science and Health, Western Sydney University, Penrith, NSW, Australia , Penrith (Australia)
Published Article
Sports Medicine - Open
Springer International Publishing
Publication Date
Feb 13, 2020
DOI: 10.1186/s40798-020-0242-8
Springer Nature


Prostate cancer has the second highest incidence of all cancers amongst men worldwide. Androgen deprivation therapy (ADT) remains a common form of treatment. However, in reducing serum testosterone to castrate levels and rendering men hypogonadal, ADT contributes to a myriad of adverse effects which can affect prostate cancer prognosis. Physical activity is currently recommended as synergistic medicine in prostate cancer patients to alleviate the adverse effects of treatment. Progressive resistance training (PRT) is an anabolic exercise modality which may be of benefit in prostate cancer patients given its potency in maintaining and positively adapting skeletal muscle. However, currently, there is a scarcity of RCTs which have evaluated the use of isolated PRT in counteracting the adverse effects of prostate cancer treatment. Moreover, although physical activity in general has been found to reduce relapse rates and improve survival in prostate cancer, the precise anti-oncogenic effects of specific exercise modalities, including PRT, have not been fully established. Thus, the overall objective of this article is to provide a rationale for the in-depth investigation of PRT and its biological effects in men with prostate cancer on ADT. This will be achieved by (1) summarising the metabolic effects of ADT in patients with prostate cancer and its effect on prostate cancer progression and prognosis, (2) reviewing the existing evidence regarding the metabolic benefits of PRT in this cohort, (3) exploring the possible oncological pathways by which PRT can affect prostate cancer prognosis and progression and (4) outlining avenues for future research.

Report this publication


Seen <100 times