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Advantage of urine based molecular diagnosis of Zika virus

Authors
  • Lamb, Laura E.1, 2
  • Bartolone, Sarah N.1
  • Kutluay, Sebla B.3
  • Robledo, Daniela4, 5
  • Porras, Alexandra6
  • Plata, Mauricio4, 5
  • Chancellor, Michael B.1, 2
  • 1 William Beaumont Hospital, Department of Urology, 3811 West 13 Mile Road, Suite 187, Royal Oak, MI, 48073, USA , Royal Oak (United States)
  • 2 Oakland University William Beaumont School of Medicine, Department of Urology, Royal Oak, MI, USA , Royal Oak (United States)
  • 3 Washington University in St. Louis, Department of Molecular Microbiology, St. Louis, MO, USA , St. Louis (United States)
  • 4 Fundación Santa Fe de Bogotá University Hospital, Department of Urology, Bogotá D.C., Colombia , Bogotá D.C. (Colombia)
  • 5 Universidad de Los Andes, School of Medicine, Bogotá D.C., Colombia , Bogotá D.C. (Colombia)
  • 6 Fundación Santa Fe de Bogotá University Hospital, Subdireccion de Estudios Clínicos, Bogotá D.C., Colombia , Bogotá D.C. (Colombia)
Type
Published Article
Journal
International Urology and Nephrology
Publisher
Springer-Verlag
Publication Date
Aug 27, 2016
Volume
48
Issue
12
Pages
1961–1966
Identifiers
DOI: 10.1007/s11255-016-1406-9
Source
Springer Nature
Keywords
License
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Abstract

Zika virus (ZIKV) infection is an emerging global health concern, and diagnostic recommendations are currently developing based on new information. Several case or small sample size studies using both urine and blood samples suggest that ZIKV RNA can be detected at higher levels and for a longer time after onset of infection in urine compared to blood. We recommend that urine and serum collection for molecular testing be a standard part of evaluating patients for ZIKV infection, and that urine is a good alternative testing sample when blood collection is problematic.

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