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Advances in understanding of angioimmunoblastic T-cell lymphoma

Authors
  • Chiba, Shigeru1
  • Sakata-Yanagimoto, Mamiko1
  • 1 University of Tsukuba,
Type
Published Article
Journal
Leukemia
Publisher
Springer Nature
Publication Date
Jul 23, 2020
Volume
34
Issue
10
Pages
2592–2606
Identifiers
DOI: 10.1038/s41375-020-0990-y
PMID: 32704161
PMCID: PMC7376827
Source
PubMed Central
Keywords
License
Unknown

Abstract

It has been nearly half a century since angioimmunoblastic T-cell lymphoma (AITL) was characterized in the early 1970’s. Our understanding of the disease has dramatically changed due to multiple discoveries and insights. One of the key features of AITL is aberrant immune activity. Although AITL is now understood to be a neoplastic disease, pathologists appreciated that it was an inflammatory condition. The more we understand AITL at cellular and genetic levels, the more we view it as both a neoplastic and an inflammatory disease. Here, we review recent progress in our understanding of AITL, focusing on as yet unsolved questions.

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