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Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases

Authors
  • Hua, Yanan1
  • Song, Jinlian2
  • Peng, Cuixiu3
  • Wang, Runze3
  • Ma, Zhongliang4
  • Zhang, Jinyu3
  • Zhang, Zheng3
  • Li, Ning3
  • Hou, Lin3
  • 1 Department of Neurobiology, Basic Medical College, Qingdao University, Qingdao , (China)
  • 2 Department of Laboratory, Women and Children’s Hospital of Qingdao, Qingdao , (China)
  • 3 Department of Biochemistry and Molecular Biology, Basic Medical College, Qingdao University, Qingdao , (China)
  • 4 Department of Breast Surgery, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao , (China)
Type
Published Article
Journal
Frontiers in Cell and Developmental Biology
Publisher
Frontiers Media SA
Publication Date
Feb 25, 2021
Volume
9
Identifiers
DOI: 10.3389/fcell.2021.620925
Source
Frontiers
Keywords
Disciplines
  • Cell and Developmental Biology
  • Review
License
Green

Abstract

A regulator of ribosome synthesis 1 (RRS1) was discovered in yeast and is mainly localized in the nucleolus and endoplasmic reticulum. It regulates ribosomal protein, RNA biosynthesis, and protein secretion and is closely involved in cellular senescence, cell cycle regulation, transcription, translation, oncogenic transformation etc., Mutations in the RRS1 gene are associated with the occurrence and development of Huntington’s disease and cancer, and overexpression of RRS1 promotes tumor growth and metastasis. In this review, the structure, function, and mechanisms of RRS1 in various diseases are discussed.

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