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Advances in paper-based sample pretreatment for point-of-care testing.

Authors
  • Tang, Rui Hua1, 2, 3, 4
  • Yang, Hui1, 2
  • Choi, Jane Ru3, 4, 5
  • Gong, Yan3, 4
  • Feng, Shang Sheng3, 4
  • Pingguan-Murphy, Belinda5
  • Huang, Qing Sheng1, 2
  • Shi, Jun Ling1, 2
  • Mei, Qi Bing1, 2
  • Xu, Feng3, 4
  • 1 a School of Life Sciences, Northwestern Polytechnical University , Xi'an , P.R. China.
  • 2 b Key Laboratory for Space Bioscience and Biotechnology , Northwestern Polytechnical University , Xi'an , P.R. China.
  • 3 c The Key Laboratory of Biomedical Information Engineering of Ministry of Education , School of Life Science and Technology, Xi'an Jiaotong University , Xi'an , P.R. China.
  • 4 d Bioinspired Engineering and Biomechanics Center (BEBC) , Xi'an Jiaotong University , Xi'an , P.R. China.
  • 5 e Department of Biomedical Engineering, Faculty of Engineering , University of Malaya , Lembah Pantai , Kuala Lumpur , Malaysia.
Type
Published Article
Journal
Critical reviews in biotechnology
Publication Date
June 2017
Volume
37
Issue
4
Pages
411–428
Identifiers
DOI: 10.3109/07388551.2016.1164664
PMID: 27075621
Source
Medline
Keywords
License
Unknown

Abstract

In recent years, paper-based point-of-care testing (POCT) has been widely used in medical diagnostics, food safety and environmental monitoring. However, a high-cost, time-consuming and equipment-dependent sample pretreatment technique is generally required for raw sample processing, which are impractical for low-resource and disease-endemic areas. Therefore, there is an escalating demand for a cost-effective, simple and portable pretreatment technique, to be coupled with the commonly used paper-based assay (e.g. lateral flow assay) in POCT. In this review, we focus on the importance of using paper as a platform for sample pretreatment. We firstly discuss the beneficial use of paper for sample pretreatment, including sample collection and storage, separation, extraction, and concentration. We highlight the working principle and fabrication of each sample pretreatment device, the existing challenges and the future perspectives for developing paper-based sample pretreatment technique.

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