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Advances in cancer imaging require renewed radiotherapy dose and target volume concepts.

Authors
  • Kaanders, Johannes H A M1
  • van den Bosch, Sven2
  • Dijkema, Tim2
  • Al-Mamgani, Abrahim3
  • Raaijmakers, Cornelis P J4
  • Vogel, Wouter V5
  • 1 Department of Radiation Oncology Radboudumc, Nijmegen, The Netherlands. Electronic address: [email protected] , (Netherlands)
  • 2 Department of Radiation Oncology Radboudumc, Nijmegen, The Netherlands. , (Netherlands)
  • 3 Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. , (Netherlands)
  • 4 Department of Radiation Oncology, University Medical Center Utrecht, The Netherlands. , (Netherlands)
  • 5 Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands. , (Netherlands)
Type
Published Article
Journal
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Publication Date
Apr 23, 2020
Volume
148
Pages
140–142
Identifiers
DOI: 10.1016/j.radonc.2020.04.016
PMID: 32361663
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Advances in diagnostic imaging create opportunities for improved therapeutic targeting of cancer but conceptual thinking about radiotherapy target volume definition and dose-prescription is not keeping up. In this opinion paper we discuss how modern imaging can contribute to new concepts for radiotherapy dose-prescription and target volume definition illustrated by the example of head and neck cancer. These new insights have the potential to significantly reduce radiation associated toxicity and may have important impact on the combination of radiotherapy with systemic cancer therapies. Copyright © 2020 Elsevier B.V. All rights reserved.

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