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[Advances in Biomarkers of Mild Traumatic Brain Injury in Cerebrospinal Fluid and Blood].

Authors
  • Huang, Wen
  • Li, Shang-xun
  • Li, Xue-jian
  • Xu, Hong-yun
Type
Published Article
Journal
Fa yi xue za zhi
Publication Date
Dec 01, 2015
Volume
31
Issue
6
Pages
466–469
Identifiers
PMID: 27141807
Source
Medline
License
Unknown

Abstract

Mild traumatic brain injury (MTBI) is defined as a mild brain trauma resulting in a short loss of consciousness and alteration of mental status. It may also occasionally develop persistent and progressive symptoms. It has been confirmed that MTBI causes changes of anatomic structures in central nervous system and biomarkers in the body fluid. However, there is no sufficient research on relevance among threshold for the brain injury, individual vulnerability and duration of disturbance of consciousness. Furthermore, there are no reliable diagnostic methods to establish whether a blow to the head is sufficient to cause the brain injury. This review provides references for biomarkers in cerebrospinal fluid and blood associated with TBI. It also provides application status and potential prospects for further assessment and diagnosis of MTBI.

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