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Advanced imaging in COPD: insights into pulmonary pathophysiology.

Authors
  • Milne, Stephen
  • King, Gregory G
Type
Published Article
Journal
Journal of thoracic disease
Publication Date
Nov 01, 2014
Volume
6
Issue
11
Pages
1570–1585
Identifiers
DOI: 10.3978/j.issn.2072-1439.2014.11.30
PMID: 25478198
Source
Medline
Keywords
License
Unknown

Abstract

Chronic obstructive pulmonary disease (COPD) involves a complex interaction of structural and functional abnormalities. The two have long been studied in isolation. However, advanced imaging techniques allow us to simultaneously assess pathological processes and their physiological consequences. This review gives a comprehensive account of the various advanced imaging modalities used to study COPD, including computed tomography (CT), magnetic resonance imaging (MRI), and the nuclear medicine techniques positron emission tomography (PET) and single-photon emission computed tomography (SPECT). Some more recent developments in imaging technology, including micro-CT, synchrotron imaging, optical coherence tomography (OCT) and electrical impedance tomography (EIT), are also described. The authors identify the pathophysiological insights gained from these techniques, and speculate on the future role of advanced imaging in both clinical and research settings.

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