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Advanced glycation end product (AGE)-induced proliferation of HEL cells via receptor for AGE-related signal pathways.

Authors
Type
Published Article
Journal
International journal of oncology
Publication Date
Volume
33
Issue
3
Pages
493–501
Identifiers
PMID: 18695878
Source
Medline
License
Unknown

Abstract

This study investigated whether advanced glycation end products (AGE) and RAGE (receptor for AGE) are involved in the proliferation of leukemia cells. AGE strongly induced the proliferation of primary acute myeloid leukemia (AML) cells and cell lines. MAP kinase, PI3K and JAK/STAT pathways were involved in cellular proliferation of HEL cells by AGE. RAGE antisense S-ODN effectively inhibited cell growth, induced apoptosis and reversed AGE-induced expression of targeting molecules in HEL cells. The study demonstrated for the first time that AGE directly induced human AML cell proliferation via the MAPK, PI3K and JAK/STAT pathways.

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