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Advanced detection strategies for cardiotropic virus infection in a cohort study of heart failure patients

Authors
  • Hanson, Paul J.1, 2
  • Liu-Fei, Felicia1
  • Minato, Taylor A.1
  • Hossain, Al Rohet1
  • Rai, Harpreet3
  • Chen, Victoria A.1
  • Ng, Coco1
  • Ask, Kjetil3
  • Hirota, Jeremy A.3
  • McManus, Bruce M.1, 2, 4
  • 1 UBC Centre for Heart Lung Innovation,
  • 2 UBC Department of Pathology and Laboratory Medicine,
  • 3 McMaster University,
  • 4 PROOF Centre of Excellence,
Type
Published Article
Journal
Laboratory Investigation
Publisher
Springer Nature
Publication Date
Oct 04, 2021
Pages
1–11
Identifiers
DOI: 10.1038/s41374-021-00669-4
PMID: 34608239
PMCID: PMC8488924
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

The prevalence and contribution of viruses to heart failure phenotypes are increasingly recognized, while still underappreciated and underreported. We designed a tissue microarray with cardiac muscle tissue from 78 heart failure patients and probed for common cardiotropic viruses via in situ hybridization. Viral RNA was detected in 46.4% of patients, higher than anticipated for these heart failure conditions that include those not previously associated with a viral trigger or an exacerbating role.

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