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Adult T-cell leukemia-associated antigen (ATLA) and anti-ATLA antibodies in patients with Hodgkin's disease in the Nagasaki District.

Authors
  • Kinoshita, K
  • Amagasaki, T
  • Yamada, Y
  • Ikeda, S
  • Momita, S
  • Toriya, K
  • Kamihira, S
  • Ichimaru, M
Type
Published Article
Journal
Japanese journal of clinical oncology
Publication Date
Jan 01, 1983
Volume
13 Suppl 2
Pages
309–311
Identifiers
PMID: 6603539
Source
Medline
License
Unknown

Abstract

Seven patients with Hodgkin's disease in the Nagasaki district were examined for adult T-cell leukemia-associated antigen (ATLA), a human retrovirus-associated antigen, and anti-ATLA antibodies. Anti-ATLA antibody reactivity with the ATLA-positive cultured cells from an ATL patient was demonstrated in four (57.1%) of seven patients. This suggests that infection by a human retrovirus may be closely associated with Hodgkin's disease in the Nagasaki district. However, ATLA could not be induced in the cultured mononuclear cells taken from biopsied lymph nodes of the three patients examined. Hence, it is necessary to collect more direct evidence in the search for a viral etiology of Hodgkin's disease.

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