Affordable Access

Access to the full text

Adult pulmonary Langerhans cell histiocytosis revealed by central diabetes insipidus: A case report and literature review

Authors
  • Lourenço, Jorge1
  • Ferreira, Cristina2
  • Marado, Daniela1
  • 1 Department of Internal Medicine, Coimbra University Central Hospital, 3000-075 Coimbra, Portugal
  • 2 Department of Pneumology, Coimbra University Central Hospital, 3000-075 Coimbra, Portugal
Type
Published Article
Journal
Molecular and Clinical Oncology
Publisher
D.A. Spandidos
Publication Date
Jul 22, 2020
Volume
13
Issue
4
Identifiers
DOI: 10.3892/mco.2020.2100
PMID: 32765877
PMCID: PMC7403809
Source
PubMed Central
Keywords
License
Green

Abstract

Langerhans cell histiocytosis (LCH) is a rare systemic and heterogeneous disease secondary to proliferation and diffuse infiltration of immature CD1a-positive dendritic cells, also known as Langerhans cells. LCH affects predominantly paediatric patients and is rarely diagnosed in adulthood. Despite its worldwide prevalence, most reported cases are found in the Japanese population. There is no consensus regarding treatment strategy due to the low incidence of this disease and the diversity of symptoms that appear. An integrative literature review was conducted based on the PubMed database using MeSH terms ‘Langerhans’, ‘histiocytosis’ and ‘adult’. The present report describes a case of a successfully treated LCH-induced central diabetes insipidus (uncommon presentation in adult patients) as well as an updated review of current evidence published on this matter.

Report this publication

Statistics

Seen <100 times