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Adult neuroplasticity: more than 40 years of research.

Authors
  • Fuchs, Eberhard1
  • Flügge, Gabriele2
  • 1 German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany ; Department of Neurology, Medical School, University of Göttingen, 37075 Göttingen, Germany. , (Germany)
  • 2 German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany. , (Germany)
Type
Published Article
Journal
Neural plasticity
Publication Date
Jan 01, 2014
Volume
2014
Pages
541870–541870
Identifiers
DOI: 10.1155/2014/541870
PMID: 24883212
Source
Medline
License
Unknown

Abstract

Within the last four decades, our view of the mature vertebrate brain has changed significantly. Today it is generally accepted that the adult brain is far from being fixed. A number of factors such as stress, adrenal and gonadal hormones, neurotransmitters, growth factors, certain drugs, environmental stimulation, learning, and aging change neuronal structures and functions. The processes that these factors may induce are morphological alterations in brain areas, changes in neuron morphology, network alterations including changes in neuronal connectivity, the generation of new neurons (neurogenesis), and neurobiochemical changes. Here we review several aspects of neuroplasticity and discuss the functional implications of the neuroplastic capacities of the adult and differentiated brain with reference to the history of their discovery.

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