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Adrenal, kidney, and heart angiotensins in female murine Ren-2 transfected hypertensive rats.

Authors
  • Senanayake, P S
  • Smeby, R R
  • Martins, A S
  • Moriguchi, A
  • Kumagai, H
  • Ganten, D
  • Brosnihan, K B
Type
Published Article
Journal
Peptides
Publisher
Elsevier
Publication Date
Jan 01, 1998
Volume
19
Issue
10
Pages
1685–1694
Identifiers
PMID: 9880073
Source
Medline
License
Unknown

Abstract

We analyzed by high-performance liquid chromatography and radioimmunoassay angiotensin I (Ang I), Ang II, Ang-(1-7), and metabolites in the adrenal, kidney and heart of normotensive female Sprague-Dawley (SD) and transgenic hypertensive [TGR(mRen-2)27] rats carrying the murine Ren-2d renin gene. The monogenetic model of hypertensive rats had significant increases in adrenal Ang II; whereas in the kidney Ang II was unchanged, but Ang I and Ang-(1-7) were significantly lower. Cardiac Ang I, Ang II, and Ang-(2-10) were significantly reduced in transgenic rats, while Ang-(2-7) was increased. In SD and transgenic rats kidney and adrenal angiotensins increased primarily during estrus or proestrus. In female transgenic rats the increased adrenal Ang II and the sustained renal Ang II may contribute to the established phase of hypertension.

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