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Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury.

Authors
  • Asai, Hiroaki
  • Fujiwara, Hiroshi
  • Kitazawa, Sohei
  • Kobayashi, Naoto
  • Ochi, Toshiki
  • Miyazaki, Yukihiro
  • Ochi, Fumihiro
  • Akatsuka, Yoshiki
  • Okamoto, Sachiko
  • Mineno, Junichi
  • Kuzushima, Kiyotaka
  • Ikeda, Hiroaki
  • Shiku, Hiroshi
  • Yasukawa, Masaki
Type
Published Article
Journal
Journal of hematology & oncology
Publication Date
Jan 01, 2014
Volume
7
Pages
3–3
Identifiers
DOI: 10.1186/1756-8722-7-3
PMID: 24393438
Source
Medline
License
Unknown

Abstract

Because WT1 is expressed in leukemia cells, the development of cancer immunotherapy targeting WT1 has been an attractive translational research topic. However, concern of this therapy still remains, since WT1 is abundantly expressed in renal glomerular podocytes. In the present study, we clearly showed that WT1-specific cytotoxic T lymphocytes (CTLs) certainly exerted cytotoxicity against podocytes in vitro; however, they did not damage podocytes in vivo. This might be due to the anatomical localization of podocytes, being structurally separated from circulating CTLs in glomerular capillaries by an exceptionally thick basement membrane.

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