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Adolescents' dietary polyphenol intake in relation to serum total antioxidant capacity: the HELENA study.

  • Wisnuwardani, Ratih W1, 2
  • De Henauw, Stefaan1
  • Forsner, Maria3, 4
  • Gottrand, Frédéric5, 6
  • Huybrechts, Inge1, 6
  • Kafatos, Antonios G7
  • Kersting, Mathilde8
  • Knaze, Viktoria6
  • Manios, Yannis9
  • Nova, Esther10
  • Molnár, Dénes11
  • Rothwell, Joseph A6
  • Scalbert, Augustin6
  • Sette, Stefania12
  • Widhalm, Kurt13
  • Moreno, Luis A14
  • Michels, Nathalie1
  • 1 Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. , (Belgium)
  • 2 Faculty of Public Health, Mulawarman University, Samarinda, East Kalimantan, Indonesia. , (Indonesia)
  • 3 Department of Nursing, Umeå University, Umeå, Sweden. , (Sweden)
  • 4 School of Education, Health and Social Sciences, Dalarna University, Falun, Sweden. , (Sweden)
  • 5 CHU Lille, Inserm U995, Univ. Lille, Lille, France. , (France)
  • 6 International Agency for Research on Cancer, Lyon Cedex 08, France. , (France)
  • 7 Clinic of Nutrition and Disease Prevention, School of Medicine, University of Crete, Crete, Greece. , (Greece)
  • 8 Research Department of Child Nutrition, Pediatric University Clinic, Ruhr-University Bochum, Bochum, Germany. , (Germany)
  • 9 Department of Nutrition and Dietetics, Harokopio University, Athens, Greece. , (Greece)
  • 10 Department of Metabolism & Nutrition, Immunonutrition Research Group, Institute of Food Science, Technology and Nutrition, Madrid, Spain. , (Spain)
  • 11 Departments of Pediatrics, Medical School, University of Pécs, Pécs, Hungary. , (Hungary)
  • 12 CREA Research Centre for Food and Nutrition, Rome, Italy. , (Italy)
  • 13 Department of Pediatric, Division of Clinical Nutrition, Medical University of Vienna, Vienna, Austria. , (Austria)
  • 14 Faculty of Health Science, GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain. , (Spain)
Published Article
International journal of food sciences and nutrition
Publication Date
Feb 01, 2022
DOI: 10.1080/09637486.2021.1910631
PMID: 33858286


We evaluated the association between intake of total polyphenols, polyphenol classes and the 10 most consumed individual polyphenols with serum total antioxidant capacity (TAC) in 749 European adolescents (53% girls; 15% overweight; 12.5-17.5 years-old) from the cross-sectional HELENA study of 2006-2007. Dietary polyphenol intake was calculated from two non-consecutive 24-h recalls matched with the Phenol-Explorer database. Multilevel linear models examined the associations between dietary polyphenols and TAC. Polyphenol intake was rather low (median = 321mg/day; p25 = 158; p75 = 536) and TAC was comparable to other literature findings (median = 1.57 mmol/L; p25 = 1.45; p75 = 1.74). Total polyphenol intake, polyphenol classes and the top 10 compounds were not associated with TAC in a linear, quadratic or cubic way in partially or fully confounder-adjusted models. A direct anti-oxidative effect of dietary polyphenol intake was not observed in European adolescents. Polyphenol biomarkers and additional antioxidant measures are needed in future prospective studies to confirm these results.

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