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Adjuvants and their signaling pathways: beyond TLRs

Authors
  • Lien, Egil1
  • Golenbock, Douglas T1
  • 1 University of Massachusetts Medical School, 364 Plantation Street, Lazare Research Building 308, Worcester, Massachusetts, 01605, USA , Worcester (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Dec 01, 2003
Volume
4
Issue
12
Pages
1162–1164
Identifiers
DOI: 10.1038/ni1203-1162
Source
Springer Nature
License
Yellow

Abstract

TLR ligands mediate adjuvant effects. Unlike lipopolysaccharide, poly(I:C) is capable of using a TLR-Trif–independent pathway to induce costimulatory molecule upregulation on antigen-presenting cells.

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