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The adjuvant-like activity of staphylococcal enterotoxin B in a murine asthma model is independent of IL-1R signaling.

Authors
  • Krysko, O
  • Maes, T
  • Plantinga, M
  • Holtappels, G
  • Imiru, R
  • Vandenabeele, P
  • Joos, G
  • Krysko, D V
  • Bachert, C
Type
Published Article
Journal
Allergy
Publication Date
Apr 01, 2013
Volume
68
Issue
4
Pages
446–453
Identifiers
DOI: 10.1111/all.12102
PMID: 23347053
Source
Medline
License
Unknown

Abstract

We provide new insights into the mechanisms of airways allergy development in the presence of bacterial superantigen. The asthma features induced by OVA+SEB, such as bronchial eosinophilia, goblet cell proliferation, production of OVA-specific IgE and increase in inflammatory dendritic cells, are IL-1R independent. Yet, IL-1R signaling is crucial for CD4 cell accumulation and Th2 cytokine production.

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