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Adipose-derived stromal cells protect intervertebral disc cells in compression: implications for stem cell regenerative disc therapy.

Authors
  • Sun, Zhen
  • Luo, Beier
  • Liu, Zhi-Heng
  • Samartzis, Dino
  • Liu, Zhongyang
  • Gao, Bo
  • Huang, Liangliang
  • Luo, Zhuo-Jing
Type
Published Article
Journal
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Publication Date
Jan 01, 2015
Volume
11
Issue
2
Pages
133–143
Identifiers
DOI: 10.7150/ijbs.10598
PMID: 25561896
Source
Medline
Keywords
License
Unknown

Abstract

Our study is the first in vitro study assessing the impact of ADSCs on NP cells in an un-physiological mechanical stimulation culture environment. Our study noted that ADSCs protect compressive load induced NP cell death and degradation by inhibition of activated caspase-9 and -3 activity; regulating ECM and modulator genes, suppressing pro-inflammatory factors and preserving CK8. Consequently, the protective impact of ADSCs found in this study provides an essential understanding and expands our knowledge as to the utility of ADSCs therapy for intervertebral disc regeneration.

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