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Adipose-derived stem cells: selecting for translational success.

Authors
  • Johal, Kavan S1
  • Lees, Vivien C
  • Reid, Adam J
  • 1 Blond McIndoe Laboratories, Institute of Inflammation & Repair, School of Medicine, University of Manchester, M13 9PT, UK.
Type
Published Article
Journal
Regenerative medicine
Publication Date
Jan 01, 2015
Volume
10
Issue
1
Pages
79–96
Identifiers
DOI: 10.2217/rme.14.72
PMID: 25562354
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We have witnessed a rapid expansion of in vitro characterization and differentiation of adipose-derived stem cells, with increasing translation to both in vivo models and a breadth of clinical specialties. However, an appreciation of the truly heterogeneous nature of this unique stem cell group has identified a need to more accurately delineate subpopulations by any of a host of methods, to include functional properties or surface marker expression. Cells selected for improved proliferative, differentiative, angiogenic or ischemia-resistant properties are but a few attributes that could prove beneficial for targeted treatments or therapies. Optimizing cell culture conditions to permit re-introduction to patients is critical for clinical translation.

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