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Adipocyte-derived players in hematologic tumors: useful novel targets?

Authors
  • Jöhrer, Karin
  • Ploner, Christian
  • Thangavadivel, Shanmugapriya
  • Wuggenig, Philipp
  • Greil, Richard
Type
Published Article
Journal
Expert Opinion on Biological Therapy
Publisher
Informa UK (Ashley Publications)
Publication Date
Jan 01, 2015
Volume
15
Issue
1
Pages
61–77
Identifiers
DOI: 10.1517/14712598.2015.970632
PMID: 25308972
Source
Medline
Keywords
License
Unknown

Abstract

Targeting lipid metabolism of cancer cells and adipocytes in combination with standard therapeutics might open novel therapeutic avenues in these cancer entities. Adipocyte-derived products such as free fatty acids and specific adipokines such as adiponectin may be vital anti-cancer targets in hematologic malignancies. However, available data on lipid metabolism is currently mostly referring to peripheral fat cell/cancer cell interactions and results need to be evaluated specifically for the bone marrow niche.

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