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Modification of Interleukin-15 Serum Levels in Workers Exposed to Chemotherapeutic Agents

Authors
Journal
Mediators of Inflammation
0962-9351
Publisher
Hindawi Publishing Corporation
Publication Date
Volume
2005
Issue
1
Identifiers
DOI: 10.1155/mi.2005.60
Keywords
  • Rapid Communication
Disciplines
  • Medicine

Abstract

Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer.

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