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Adenoviral-mediated skeletal muscle transcriptional targeting using chimeric tissue-specific promoters.

Authors
  • Frauli, Mélanie
  • Ribault, Sébastien
  • Neuville, Pascal
  • Augé, Fabrice
  • Calenda, Valérie
Type
Published Article
Journal
Medical science monitor : international medical journal of experimental and clinical research
Publication Date
Feb 01, 2003
Volume
9
Issue
2
Identifiers
PMID: 12601283
Source
Medline
License
Unknown

Abstract

Chimeric regulatory sequences based on the skeletal a-actin promoter are highly specific and allow transgene expression in vivo at high levels. These results indicate that expression cassettes designed for the treatment of peripheral ischemia by gene therapy can efficiently target gene expression to skeletal muscle.

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