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ADENOSYLMETHIONINE ELEVATION IN LEUKEMIC WHITE BLOOD CELLS.

Authors
  • BALDESSARINI, R J
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Aug 06, 1965
Volume
149
Issue
3684
Pages
644–645
Identifiers
PMID: 14331187
Source
Medline
Keywords
License
Unknown

Abstract

White blood cell preparations from patients with chronic myelocytic leukemia have more S-adenosylmethionine, an important metabolic intermediate, than normal peripheral white cells or thoracic-duct lymphocytes. The previously reported elevation of cyanocobalamine (vitamin B(l2)) in the serum of patients with this disease is corroborated. The possible usefulness of methylation antimetabolites in cancer chemotherapy is suggested.

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