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Adenosine diphosphate binding to sodium-plus-potassium ion-dependent adenosine triphosphatase. The role of lipid in the nucleotide-potassium ion interplay.

Authors
  • J Jensen
  • P Ottolenghi
Publication Date
Dec 01, 1976
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

Delipidated dogfish rectal-gland Na++K+-ATPase (Na++K+-dependent adenosine triphosphatase), almost devoid of hydrolytic activity, is able to bind about 2nmol of ADP/mg of protein. The "affinity" of delipidated enzyme for ADP is not affected by K+ in concentrations that greatly decrease the "affinity" of native Na++K+-ATPase. The K+-sensitivity of the ADP binding is in part restored by relipidation with dioleoyl phosphatidylcholine.

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