Ports are strategic hubs of the logistic chain and are likely to be exposed to natural hazard events. Variation of metocean agents derived from climate change, such as sea level rise or changes in the magnitude, frequency, duration, and direction of storms, can modify the infrastructural and operational vulnerability of port areas and activities, demanding the development of adaptation or mitigation strategies. In this context, the present paper is aimed to propose a downscaling methodology for addressing local effects at port scale. In addition, based on previously identifying and defining the Areas of Operational Interest (AOIs) inside ports, an approach towards the evaluation of operational vulnerability is offered. The whole process is applied, as a practical case, to the Port of Gijó / n (Spain) for different General Circulation Models (GCMs), concentration scenarios, and time horizons. The results highlight, in line with other publications, that inter-model differences are, so far, more significant than intra-model differences from dissimilar time horizons or concentration scenarios.