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Effect of topical cyclophosphamide, methotrexate and vinblastine on 9,10-dimethyl-1,2-benzanthracene (DMBA)—Carcinogenesis in the hamster cheek pouch

Authors
Journal
European Journal of Cancer (1965)
0014-2964
Publisher
Elsevier
Publication Date
Volume
6
Issue
3
Identifiers
DOI: 10.1016/0014-2964(70)90021-6
Disciplines
  • Medicine

Abstract

Abstract In hamster cheek pouches treated topically with DMBA 3 times per week during 6 or 12 weeks, concurrent topical application on alternate days of cyclophosphamide, methotrexate, or vinblastine, caused inhibition of tumor formation to varying degrees. Tumor inhibition was most marked with vinblastine and much less with methotrexate and cyclophosphamide. When hamster cheek pouch lesions, induced previously with DMBA during 6 weeks were subsequently treated topically with cytostatic drugs during 6 weeks, vinblastine completely suppressed the further development of DMBA-induced lesions, but topical cyclophosphamide had only a slight effect, and the effect of methotrexate was minimal. Topical cytostatic treatment of cheek pouch lesions induced by previous application of DMBA during 12 weeks had no therapeutic effect.

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