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ADC correlation with Sirtuin1 to assess early chemoradiotherapy response of locally advanced esophageal carcinoma patients

Authors
  • Chen, Ying1, 2, 3
  • Xie, Tieming1, 4, 5
  • Ye, Zhimin1, 2, 3
  • Wang, Fangzheng1, 2, 3
  • Long, Dan1, 4, 5
  • Jiang, Mingxiang1, 4, 5
  • Fang, Jun1, 2, 3
  • Lin, Qingren1, 2, 3
  • Li, Kai1, 4, 5
  • Wang, Zhun1, 2, 3
  • Fu, Zhenfu1, 2, 3
  • 1 Chinese Academy of Sciences, Institute of Cancer and Basic Medine (ICBM), Hangzhou, People’s Republic of China , Hangzhou (China)
  • 2 Cancer Hospital of the University of Chinese Academy of Sciences, Department of Radiation Oncology, No. 1 Banshan East Road, Hangzhou, 310022, People’s Republic of China , Hangzhou (China)
  • 3 Zhejiang Cancer Hospital, Department of Radiation Oncology, No.1 of Banshan East Road, Hangzhou, 310022, People’s Republic of China , Hangzhou (China)
  • 4 Cancer Hospital of the University of Chinese Academy of Sciences, Department of Radiology, Hangzhou, 310022, People’s Republic of China , Hangzhou (China)
  • 5 Zhejiang Cancer hospital, Department of Radiology, No.1 of Banshan East Road, Hangzhou, 310022, People’s Republic of China , Hangzhou (China)
Type
Published Article
Journal
Radiation Oncology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Nov 04, 2019
Volume
14
Issue
1
Identifiers
DOI: 10.1186/s13014-019-1393-y
Source
Springer Nature
Keywords
License
Green

Abstract

AimsTo determine the biological correlation between apparent diffusion coefficient (ADC) values and Sirtuin1 (SIRT1) levels of tumour tissues in patients with esophageal carcinoma (EC), and to ascertain the treatment biomarker of ADC in predicting the early response of patients undergoing definitive chemoradiotherapy (CRT).MethodsA total of 66 patients were enrolled, and the specimens of tumour tissues were collected before treatment to perform immunohistochemical (IHC) examinations and quantify the levels of SIRT1. Then all patients were given two esophageal magnetic resonance imaging (MRI) examinations with diffused weighed imaging (DWI) including pretreatment and intra-treatment (1~2 weeks after the start of radiotherapy). The regions of interest (ROIs) were contoured according to the stipulated rules in advance using off-line software, and the values of the ADC in the ROIs were generated automatically. Then, the values of the ADC at baseline and intra-treatment were labeled as pre-ADC and intra-ADC respectively, and ΔADC, ADCratio were calculated. Pearson’s correlation coefficients were acquired to estimate the correlation between each of ADC values and SIRT1 levels. Spearman’s rank correlation coefficients were acquired to estimate the correlation between early response and the values of each ADC. Receptor operation characteristics (ROC) curves were constructed to estimate the accuracy of the ADC in predicting the early response of CRT.ResultsThe findings of this study showed different correlations between ADC values and the levels of SIRT1 (ΔADC: r = − 0.943, P = 0.002; ADCratio: r = − 0.911, P = 0.000; intra-ADC: r = − 0.748, P = 0.002; pre-ADC: r = 0.109, P = 0.558). There was a positive correlation between ΔADC and early response to treatment (ρ = 0.615, P = 0.023), and multivariable logistic regression revealed that ΔADC was significantly associated with short-term response of CRT in esophageal carcinoma patients.ConclusionsIn summary, early increases in ADC may facilitate the predication of early CRT response in patients with esophageal squamous cell carcinoma (ESCC), which may be attributed to the different correlation between ADC changes and SIRT1 expression.

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