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Stabilization of microtubules by lithium ion

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
73
Issue
2
Identifiers
DOI: 10.1016/0006-291x(76)90719-1

Abstract

Abstract Lithium ion, in concentrations of 0.2 – 1.0 mM, promotes tubulin polymerization, provided small concentrations of Mg ++ ion are present. This effect of lithium on polymerization, at suboptimal concentration of magnesium, is additive for the two metal ions. Both Li + and Mg ++ protect microtubules against the depolymerizing effects of colchicine or vinblastine.

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