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Transient postnatal thyroxine treatment leads to an increased number of cholinergic neurons in the medial septum and to a higher density of cholinergic fibers in hippocampal CA3 in rats

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
198
Issue
3
Identifiers
DOI: 10.1016/0304-3940(95)11997-b
Keywords
  • Cholinergic Neurons
  • Medial Septum
  • Hippocampus
  • Acetylcholinesterase
  • Cholinergic Fibers
  • Quantitative Analysis
  • Hyperthyroidism
Disciplines
  • Chemistry

Abstract

Abstract Newborn male pups of Sprague-Dawley rats received daily injections of buffered l-thyroxine or saline during the first 12 days postnatally. At the age of 12 weeks, the number of immunocytochemically labeled cholinergic neuronal profiles in the medial septum/diagonal band (MS/vDB) was counted, and the density of acetylcholinesterase (AChE)-positive fibers in four hippocampal subregions was measured. Thyroxine-treated rats had more ChAT-positive neuronal profiles in the MS/vDB and a higher density of AChE-positive fibers in hippocampal CA3 as compared to controls. From this study it is concluded that transient postnatal hyperthyroidism leads to an increased cholinergic innervation of hippocampal CA3.

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