Real-time applications, such as Multi-party conferencing systems, have strong Quality of Service requirements for ensuring a decent Quality of Experience. Nowadays, most of these conferences are performed on wireless devices. Thus, heterogeneous mobile devices and network dynamics must be properly managed to provide a good quality of experience. In this thesis, we propose two algorithms for building and maintaining conference sessions based on Software-Defined Network that uses both multicast distribution and streams adaptation. The first algorithm set up the conference call by building multicast trees for each participant. Then, it optimally places the stream adaptation locations and rules inside the network in order to minimize the bandwidth consumption. We have created two versions of this algorithm: the first one, based on the shortest path trees is minimizing the latency, while the second one, based on spanning trees is minimizing the bandwidth consumption. The second algorithm adapts the multicast trees according to the network changes occurring during a call. It does not recompute the trees, but only relocates the locations and rules of stream adaptation. It requires very low computation at the controller, thus making our proposal fast and highly reactive. Extensive simulation results confirm the efficiency of our solution in terms of processing time and bandwidth savings compared to existing conferencing systems based on a Multipoint Control Unit and Application Layer Multicast.