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Adapting genetic regulatory models by genetic programming.

Authors
  • Eriksson, R
  • Olsson, B
Type
Published Article
Journal
Biosystems
Publisher
Elsevier
Publication Date
Jan 01, 2004
Volume
76
Issue
1-3
Pages
217–227
Identifiers
PMID: 15351145
Source
Medline
License
Unknown

Abstract

In this paper, we focus on the task of adapting genetic regulatory models based on gene expression data from microarrays. Our approach aims at automatic revision of qualitative regulatory models to improve their fit to expression data. We describe a type of regulatory model designed for this purpose, a method for predicting the quality of such models, and a method for adapting the models by means of genetic programming. We also report experimental results highlighting the ability of the methods to infer models on a number of artificial data sets. In closing, we contrast our results with those of alternative methods, after which we give some suggestions for future work.

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