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Inhibition of Aggregation and Differentiation of Dictyostelium discoideum by Antibodies Against Adenosine 3′:5′-Cyclic Monophosphate Diesterase

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  • Biological Sciences: Immunology


A specific antibody directed against adenosine 3′:5′-cyclic monophosphate diesterase (c-AMP diesterase; EC 3.1.4.c), which is secreted by the amoeboid slime mold, Dictyostelium discoideum, was prepared in rabbits. Purified gammaglobulin fractions that contain the antibodies inhibited the activity of cAMP diesterase preparations in vitro and interfered with aggregation and development in vivo. While cells that were treated with antibody were unable to aggregate because of the inability to destroy cAMP, they aggregated normally when washed free of antibody.

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