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Characterization of a novel arachidonic acid-derived neutrophil chemoattractant

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
186
Issue
1
Identifiers
DOI: 10.1016/s0006-291x(05)80803-4
Disciplines
  • Medicine

Abstract

The oxidation of arachidonic acid in a superoxide-generating environment results in the formation of a potent chemoattractant that appears to be identical to a chemotactic material generated by hepatocytes when they metabolize alcohol. The product was extracted, chromatographed and characterized by physical methods including GC/MS. The physical properties are consistant with the parent structure: 19-hydroperoxy, 20-hydroxyarachidic acid. This novel saturated 20 carbon product, derived from arachidonic acid by free radical-generating reactions, may play a role in the neutrophilic infiltration observed during the course of acute alcoholic hepatitis.

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