Affordable Access

Publisher Website

Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles

Authors
Journal
Biomacromolecules
1525-7797
Publisher
American Chemical Society
Publication Date
Volume
14
Issue
4
Identifiers
DOI: 10.1021/bm3019906
Keywords
  • Article
Disciplines
  • Medicine

Abstract

Plant-derived Type I toxins are candidate anticancer therapeutics requiring cytosolic delivery into tumor cells. We tested a concept for two-stage delivery, whereby tumor cells precoated with an antibody-targeted gelonin toxin were killed by exposure to endosome-disrupting polymer nanoparticles. Co-internalization of particles and tumor cell-bound gelonin led to cytosolic delivery and >50-fold enhancement of toxin efficacy. This approach allows the extreme potency of gelonin to be focused on tumors with significantly reduced potential for off-target toxicity.

There are no comments yet on this publication. Be the first to share your thoughts.