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Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

Authors
  • Zhou, Runhong1, 2
  • To, Kelvin Kai-Wang2
  • Wong, Yik-Chun1, 2
  • Liu, Li1, 2
  • Zhou, Biao1, 2
  • Li, Xin1
  • Huang, Haode1
  • Mo, Yufei1, 2
  • Luk, Tsz-Yat1
  • Lau, Thomas Tsz-Kan1
  • Yeung, Pauline3
  • Chan, Wai-Ming4
  • Wu, Alan Ka-Lun5
  • Lung, Kwok-Cheung6
  • Tsang, Owen Tak-Yin7
  • Leung, Wai-Shing7
  • Hung, Ivan Fan-Ngai8
  • Yuen, Kwok-Yung2
  • Chen, Zhiwei1, 2
  • 1 AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), People’s Republic of China
  • 2 Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People’s Republic of China
  • 3 Department of Intensive Care, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, People’s Republic of China
  • 4 Department of Adult Intensive Care, Queen Mary Hospital, Hong Kong SAR, People’s Republic of China
  • 5 Department of Microbiology, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People’s Republic of China
  • 6 Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People’s Republic of China
  • 7 Department of Medicine, Princess Margaret Hospital, Hong Kong SAR, People’s Republic of China
  • 8 Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People’s Republic of China
Type
Published Article
Journal
Immunity
Publication Date
Aug 04, 2020
Volume
53
Issue
4
Pages
864–877
Identifiers
DOI: 10.1016/j.immuni.2020.07.026
PMID: 32791036
PMCID: PMC7402670
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

COVID-19 is an acute disease caused by SARS-CoV-2 infection. We determine how the immune system responds to SARS-CoV-2 at both acute and convalescent stages. Acute SARS-CoV-2 infection results in broad immune cell reduction and functional impairment. While neutralizing antibodies are rapidly generated, antigen-specific T cells are delayed at the acute stage.

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