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Acute renal failure due to tumor lysis syndrome in a patient with non-Hodgkin's lymphoma.

Authors
  • Karagiannis, Asterios
  • Tsorlalis, Ioannis
  • Kakafika, Anna
  • Pateinakis, Panagiotis
  • Perifanis, Vasilios
  • Harsoulis, Faidon
Type
Published Article
Journal
Annals of hematology
Publication Date
May 01, 2005
Volume
84
Issue
5
Pages
343–346
Identifiers
PMID: 15580501
Source
Medline
License
Unknown

Abstract

Tumor lysis syndrome is characterized by multiple metabolic derangements resulting from the release of intracellular components into the bloodstream due to abrupt malignant cell death, spontaneously or following antineoplastic therapy. The syndrome is characterized by hyperkalemia, hyperuricemia, hyperphosphatemia, and hypocalcemia, while deposition of uric acid and calcium phosphate crystals may result in acute renal failure, which is often exacerbated by concomitant intravascular volume depletion. A case of tumor lysis syndrome complicated by acute renal failure in a patient with non-Hodgkin's lymphoma is reported and the pathophysiology, the clinical features, and the treatment options are discussed.

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